Jian Huang

Jian Huang

PhD in Computational Biophysics


    2026

  1. Barethiya, S.; Huang, J.; Stumpf, C.; Liu, X.; Guan, H.; Chen, J. Overcoming Extrapolation Challenges of Deep Learning by Incorporating Physics in Protein Sequence-Function Modeling. PLOS Computational Biology 2026, 22 (3), e1013728. DOI.
  2. Huang, J.; Lu-Diaz, K. W.; Thompson, L.; Chen, J. Dynamic Domain Interactions Encode Possible CheA Autophosphorylation Mechanisms Revealed by Coarse-Grained Simulations. Biophys J 2026, 125 (4), 1125–1138. DOI.
  3. Lu-Diaz, K. W.; Huang, J.; Chen, J.; Fejzo, J.; Thompson, L. K. Chemotaxis Kinase CheA Is Regulated by Modulating Interdomain Interactions. Biophysical Journal 2026. DOI.

    4. 2025

  4. Nguyen, B. V.; Özden, C.; Dong, K.; Koc, O. C.; Torres-Ocampo, A. P.; Dziedzic, N.; Flaherty, D.; Huang, J.; Sankara, S.; Abromson, N. L.; Tomchick, D. R.; Fissore, R. A.; Chen, J.; Garman, S. C.; Stratton, M. M. A Domain-Swapped CaMKII Conformation Facilitates Linker-Mediated Allosteric Regulation. Nat Commun 2025, 16 (1), 8461. DOI.
  5. Huang, J.; Chen, J. PIP2 Regulation of TRPV4 Channels: Binding Sites and Dynamic Coupling. Biophysical Journal 2025, 124 (18), 3037–3048. DOI.

    6. 2024

  6. Burtscher, V.; Mount, J.; Huang, J.; Cowgill, J.; Chang, Y.; Bickel, K.; Chen, J.; Yuan, P.; Chanda, B. Structural Basis for Hyperpolarization-Dependent Opening of Human HCN1 Channel. Nat Commun 2024, 15 (1), 5216. DOI.

    7. 2023

  7. Huang, J.; Korsunsky, A.; Yazdani, M.; Chen, J. Targeting TRP Channels: Recent Advances in Structure, Ligand Binding, and Molecular Mechanisms. Front. Mol. Neurosci. 2024, 16. DOI.
  8. Huang, J.; Chen, J. Hydrophobic Gating in Bundle-Crossing Ion Channels: A Case Study of TRPV4. Commun Biol 2023, 6 (1), 1–9. DOI.

    9. 2022

  9. Jia, Z.; Huang, J.; Chen, J. Activation of TMEM16F by Inner Gate Charged Mutations and Possible Lipid/Ion Permeation Mechanisms. Biophysical Journal 2022, 121 (18), 3445–3457. DOI.

    10. 2021

  10. Xue, T.; Wu, W.; Guo, N.; Wu, C.; Huang, J.; Lai, L.; Liu, H.; Li, Y.; Wang, T.; Wang, Y. Single Point Mutations Can Potentially Enhance Infectivity of SARS-CoV-2 Revealed by in Silico Affinity Maturation and SPR Assay. RSC Adv. 2021, 11 (24), 14737–14745. DOI.
  11. Fu, Y.; Huang, J.; Wu, Y.; Liu, X.; Zhong, F.; Wang, J. Biocatalytic Cross-Coupling of Aryl Halides with a Genetically Engineered Photosensitizer Artificial Dehalogenase. J. Am. Chem. Soc. 2021, 143 (2), 617–622. DOI.